May 29, 2017. REPAGLINIDE - ORAL Prandin side effects, medical uses. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. There was no average gain in body weight when patients previously treated with oral hypoglycemic agents were switched to PRANDIN.
Tablets - Summary of Product. Repaglinide can cause low blood sugar hypoglycemia especially if you are taking other medicines for diabetes. Consuming large quantities of alcohol, not getting enough calories from food, or doing unusually heavy exercise may also lead to low blood sugar. Symptoms may include chills, cold sweat, dizziness, drowsiness, shaking, fast heartbeat, weakness, headache, fainting, tingling of the hands or feet, or hunger. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, raise your blood sugar quickly by eating a quick source of sugar such as table sugar, honey, candy, or drinking a glass of fruit juice or non-diet soda. Check with your doctor or pharmacist to find out what you should do if you miss a meal.
AUC was statistically correlated with caffeine clearance. No difference in glucose profiles was observed across patient groups. The dosing of PRANDIN relative to meal-related insulin release was studied in three trials including 58 patients. Glycemic control was maintained during a period in which the meal and dosing pattern was varied 2, 3 or 4 meals per day; before meals x 2, 3, or 4 compared with a period of 3 regular meals and 3 doses per day before meals x 3. Blood glucose-lowering effect did not differ when PRANDIN was administered at the start of a meal, 15 minutes before, or 30 minutes before the meal.
Use repaglinide regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. Other symptoms of low blood sugar such as dizziness, hunger, or sweating are unaffected by these drugs. PRANDIN was studied in combination with in 83 patients not satisfactorily controlled on exercise, diet, and metformin alone. PRANDIN dosage was titrated for 4 to 8 weeks, followed by a 3-month maintenance period. Combination therapy with PRANDIN and metformin resulted in statistically significant improvement in HbA 1c and fasting plasma glucose FPG compared to PRANDIN or metformin monotherapy Table 8. In this study where metformin dosage was kept constant, the combination therapy of PRANDIN and metformin showed dose-sparing effects with respect to PRANDIN.
Have been diabetic 18 years and have good eye sight and good kidney health so I will continue Prandin as long as the Dr. says. Easier to travel with than insulin though that worked well while i needed it too. PRANDIN therapy resulted in dose-proportional glucose lowering over the full dose range. Plasma insulin levels increased after meals and reverted toward baseline before the next meal. Most of the -lowering effect was demonstrated within 1-2 weeks. Hypoglycemia can happen suddenly and symptoms may differ in each individual and change over time in the same individual. What should I avoid while taking repaglinide Prandin? Gradually titrate the dose, if needed to achieve glycemic control. Prandin is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.
What is the most important information I should know about repaglinide Prandin? Take care not to let your blood sugar get too low. Low blood sugar hypoglycemia can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency. Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection. These data indicate that repaglinide did not accumulate in serum. Weight gain, diarrhea, and joint pain may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. slimex
RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Take Prandin exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. Combination therapy resulted in statistically significant improvement in HbA 1c and FPG compared to monotherapy Table 9 below. The glycemic effects of the combination therapy were dose-sparing with respect to both total daily PRANDIN dosage and total daily rosiglitazone dosage see Table 9 Legend. The improvement in HbA 1c and FPG of the combination therapy group was achieved with lower daily dose of PRANDIN and rosiglitazone, as compared to the respective monotherapy groups. You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. PRANDIN and metformin monotherapy. MONITOR: Grapefruit juice may increase the plasma concentrations of orally administered drugs that are substrates of the CYP450 3A4 isoenzyme. Instruct patients to take PRANDIN within 30 minutes before meals. ditel.info estreva
Consumer information about the medication REPAGLINIDE - ORAL Prandin includes side effects, drug interactions, recommended dosages, and storage information. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure convulsions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. This difference was not reflected in the frequency of episodes male: 16%; female: 17% or other adverse events. Chromium is LIKELY SAFE for most adults when taken by mouth in doses up to 1000 mcg daily for up to 6 months. Chromium is POSSIBLY SAFE for most adults when used for longer periods of time. Some people experience side effects such as skin irritation, headaches, dizziness, nausea, mood changes and impaired thinking, judgment, and coordination. High doses have been linked to more serious side effects including blood disorders, liver or kidney damage, and other problems. It is not known for sure if chromium is the actual cause of these side effects. The intra-individual and inter-individual coefficients of variation were 36% and 69%, respectively. Consumer information for this interaction is not currently available. Avoid drinking alcohol on an empty stomach or following exercise, as it may increase the risk of hypoglycemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. Store repaglinide at room temperature away from moisture and heat. Prandin is one of six types of diabetes pills currently available to treat type 2 diabetes. Remember, the cornerstone of diabetes control. Precose metformin Glucophage miglitol Glyset pioglitazone Actos, Duetact, Actoplus Met or rosiglitazone Avandia, Avandaryl, Avandamet. Also watch for signs of high blood sugar hyperglycemia such as increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Repaglinide is completely metabolized by oxidative biotransformation and direct conjugation with glucuronic acid after either an IV or oral dose. The major metabolites are an oxidized dicarboxylic acid M2 the aromatic M1 and the acyl glucuronide M7. The cytochrome P-450 enzyme system, specifically 2C8 and 3A4, have been shown to be involved in the N-dealkylation of repaglinide to M2 and the further oxidation to M1. Metabolites do not contribute to the glucose-lowering effect of repaglinide. Within 96 hours after dosing with 14C-repaglinide as a single, oral dose, approximately 90% of the radiolabel was recovered in the feces and approximately 8% in the urine. canada prazosin level
If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. The dose that achieved the targeted control or the maximum dose was continued to end of study. FPG and 2-hour post- glucose PPG increased in patients receiving placebo and decreased in patients treated with repaglinide. There are no adequate and well-controlled studies in pregnant women. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. June 3, 2017. Prandin Repaglinide: Side Effects, Interactions, Warning. florinef brand names australia
Medscape - Depression, OCD, panic disorder, PTSD, PMDD-specific dosing for Zoloft sertraline frequency-based adverse effects, comprehensive interactions. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Take the missed dose as soon as you remember, but only if you are getting ready to eat a meal. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. Avoid concomitant use of PRANDIN with clopidogrel. Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. If you miss a dose, skip that dose and resume your regular dosage schedule with your next meal. PRANDIN monotherapy, and 2% for monotherapy. Read the Patient Information leaflet if one is available from your pharmacist before you start using repaglinide and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Talk to your doctor before using ethanol together with repaglinide. Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia low blood sugar and hyperglycemia high blood sugar may occur, depending on how much and how often you drink. You should avoid using alcohol if your diabetes is not well controlled or if you have high triglycerides, neuropathy nerve damage or pancreatitis. Moderate alcohol consumption generally does not affect blood glucose levels if your diabetes is under control. PRANDIN is not indicated for use in combination with NPH-insulin. June 5, 2017. Losing Weight with Diabetes: What Prevents It and Causes. Crestor but now am wondering if it could be the Prandin?
Repaglinide was non-genotoxic in a battery of in vivo and in vitro studies: Bacterial mutagenesis in vitro forward cell mutation assay in V79 cells HGPRT in vitro chromosomal aberration assay in human lymphocytes, unscheduled and replicating DNA synthesis in rat liver, and in vivo mouse and rat micronucleus tests. Low blood sugar hypoglycemia can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency. Take this medication by mouth 15 minutes before each meal, usually 2-4 times daily depending on the number of meals or as directed by your doctor. Take this drug no earlier than 30 minutes before the meal. You may also take it just before the meal if necessary. Do not take a dose of medication if you are skipping that meal or if your blood sugar is low. How does Chromium work? Prandin is usually taken 2 to 4 times daily, within 30 minutes before eating a meal. Follow your doctor's instructions. If you skip a meal, do not take your dose of Prandin. Wait until your next meal. Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly. Do not share this medication with others. Healthy volunteers were treated with a regimen of 2 mg PRANDIN taken before each of 3 meals. acticin
How should I take repaglinide Prandin? Symptoms of high blood sugar hyperglycemia include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor. If these symptoms occur, tell your doctor right away. Your doctor may need to adjust your diabetes medications. It is not known whether Prandin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Your doctor may recommend using insulin to be sure your blood sugar is well-controlled during pregnancy. After having a stroke lost a great deal of weight and endocrinologist prescribed this and I got off insulin. Took Prandin for six months then lost more weight and stopped. Increased frequency of glucose monitoring may be required during concomitant use. Ask your doctor how to adjust your repaglinide dose if needed. Do not change your medication dose or schedule without your doctor's advice. Dispense in tight containers with safety closures. Get emergency medical help if you have any signs of an allergic reaction to Prandin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. FDA pregnancy category C. It is not known whether repaglinide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply. Hypoglycemia was reported in 16% of 1228 PRANDIN patients, 20% of 417 glyburide patients, and 19% of 81 glipizide patients in 1year controlled trials. Of PRANDIN-treated patients with symptomatic hypoglycemia, none developed coma or required hospitalization. Patients previously treated with an oral hypoglycemic or patients who have an HbA1c greater than or equal to 8%: 1 to 2 mg orally with meals. At least one week should elapse to assess response after each dose adjustment. June 16, 2017. Prandin Repaglinide: Side Effects, Interactions, Warning. Check your blood sugar regularly as directed by your doctor. Keep track of the results, and share them with your doctor. This is very important in order to determine the correct dose. Tell your doctor if your blood sugar measurements are too high or too low. Your treatment plan may need to be changed. order generic voltaren mastercard usa
The dosage is based on your medical condition and response to treatment. PRANDIN dose increases and increased frequency of glucose monitoring may be required when coadministered. Daily maximum PRANDIN dose should be limited to 6 mg, and increased frequency of glucose monitoring may be required when PRANDIN is co-administered with cyclosporine. Drugs that are known to inhibit CYP3A4 include antifungal agents ketoconazole, itraconazole and antibacterial agents clarithromycin, erythromycin. Drugs that are known to inhibit CYP2C8 include trimethoprim, gemfibrozil, montelukast, deferasirox, and clopidiogrel. Do not give this medicine to anyone under 18 years old without medical advice. selegiline without pre
How should I take Prandin? What happens if I miss a dose Prandin? Novo Nordisk Apis bull symbol. The following additional adverse reactions have been identified during post approval use of PRANDIN. Because these reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or a causal relationship to drug exposure. Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice. Table 1 lists the common adverse reactions for PRANDIN patients compared to placebo in trials 12 to 24 weeks duration. A1c should be performed periodically to check for side effects and monitor your response to treatment. Repaglinide closes -dependent channels in the ß-cell membrane by binding at characterizable sites. This potassium channel blockade depolarizes the ß-cell, which leads to an opening of calcium channels. The resulting increased calcium influx induces insulin secretion. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. The biggest problem many people have with Metformin is that it causes such misery when it hits their stomachs that they can't keep taking it even though. What should I discuss with my doctor before taking repaglinide Prandin? Although it is not known whether repaglinide is excreted in human milk some oral agents are known to be excreted by this route. Because the potential for hypoglycemia in nursing infants may exist, and because of the effects on nursing animals, a decision should be made as to whether PRANDIN should be discontinued in nursing mothers, or if mothers should discontinue nursing. If PRANDIN is discontinued and if diet alone is inadequate for controlling blood glucose, insulin therapy should be considered. In rat reproduction studies, measurable levels of repaglinide were detected in the breast milk of the dams and lowered blood glucose levels were observed in the pups. Additionally, the following drugs were studied in healthy volunteers with co-administration of PRANDIN. Why do I need Sulfonylurea agents? Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Prandin only for the indication prescribed. persantine
Your pharmacist can provide more information about repaglinide. Because clinical trials are conducted under widely varying designs, the adverse reaction rates reported in one clinical trial may not be easily compared to those rates reported in another clinical trial, and may not reflect the rates actually observed in clinical practice. In clinical studies of 24 weeks or greater duration, 415 patients were over 65 years of age and no patients were greater than 75 years of age. In one-year, active-controlled trials, no differences were seen in effectiveness or adverse events between these subjects and those less than 65. There was no increase in frequency or severity of hypoglycemia in older subjects, but greater sensitivity of some older individuals to PRANDIN therapy cannot be ruled out. Drug interaction studies performed in healthy volunteers show that PRANDIN had no clinically relevant effect on the pharmacokinetic properties of digoxin, theophylline, or warfarin. Co-administration of cimetidine with PRANDIN did not significantly alter the absorption and disposition of repaglinide. Your doctor may want you to stop taking repaglinide for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency. Also watch for signs of blood sugar that is too high hyperglycemia. These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. After single and multiple oral doses in healthy subjects or in patients, peak plasma drug levels C max occur within 1 hour T max . Repaglinide is eliminated from the blood stream with a half-life of approximately 1 hour. The mean absolute bioavailability is 56%. In this study where pioglitazone dosage was kept constant, the combination therapy group showed dose-sparing effects with respect to PRANDIN see Figure 1 Legend. The improvement in HbA 1c and FPG of the combination group was achieved at a lower daily PRANDIN dosage than in the PRANDIN monotherapy group. Do not stop taking any medications without consulting your healthcare provider. What happens if I overdose Prandin? Chromium supplements can cause allergic reactions in people with chromate or leather contact allergy. Symptoms include redness, swelling, and scaling of the skin. Behavioral or psychiatric conditions such as depression, anxiety, or schizophrenia: Chromium might affect brain chemistry and might make behavioral or psychiatric conditions worse. If you have one of these conditions, be careful when using chromium supplements. Pay attention to any changes in how you feel. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Patients with moderate to severe impairment of liver function had higher and more prolonged serum concentrations. Therefore, PRANDIN should be used cautiously in patients with impaired liver function. Longer intervals between dose adjustments may be needed to allow full assessment of response. All informations on this page are taken from public sources such as search engines yahoo. Safety and effectiveness have not been established in pediatric patients. You should not use Prandin together with gemfibrozil Lopid or NPH insulin such as isophane insulin. Patients should administer PRANDIN before meals and be instructed to skip the dose of PRANDIN if a meal is skipped. It is not known whether this drug passes into breast milk and the effect on a nursing infant is unknown. Therefore, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding. Also watch for signs of blood sugar that is too high hyperglycemia. These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Your blood sugar will need to be checked often, and you may need to adjust your repaglinide dose. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. PRANDIN is indicated as an adjunct to diet and exercise to improve glycemic control in adults with mellitus. If you are changing from a different anti-diabetes drug such as chlorpropamide to repaglinide, follow your doctor's directions carefully for stopping the old drug and starting this medication. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure convulsions. What should I avoid while taking Prandin? Prandin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels. buy genuine lamotrigine online
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PRANDIN has been administered to 2931 individuals during clinical trials. Approximately 1500 of these individuals with have been treated for at least 3 months, 1000 for at least 6 months, and 800 for at least 1 year. The majority of these individuals 1228 received PRANDIN in one of five 1-year, active-controlled trials. Over one year, 13% of PRANDIN patients were discontinued due to adverse reactions. Many other medicines that can increase or decrease the effects of Prandin on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Advair-Diskus-fluti casone-propionate-salmeterol-166 WebMD explains the causes, symptoms, and treatment of hypoglycemia, or low blood sugar, a common problem in people with diabetes. PRANDIN dosage was titrated during the first 12 weeks, followed by a 12-week maintenance period.
MANAGEMENT: Patients who regularly consume grapefruit or grapefruit juice should be monitored for adverse effects and altered plasma concentrations of drugs that undergo significant presystemic metabolism by CYP450 3A4. Grapefruit and grapefruit juice should be avoided if an interaction is suspected. Orange juice is not expected to interact with these drugs. Warnings: Pregnancy and breast-feeding: Chromium is LIKELY SAFE to use during pregnancy and breast-feeding when taken by mouth in amounts that are equal to or less than "adequate intake" AI levels. Chromium is POSSIBLY SAFE to use during pregnancy in amounts higher than the AI levels. However, pregnant women should not take chromium supplements during pregnancy or breast-feeding unless advised to do so by their healthcare provider. Kidney disease: There are at least three reports of kidney damage in patients who took chromium picolinate. Don't take chromium supplements, if you already have kidney disease. Liver disease: There are at least three reports of liver damage in patients who took chromium picolinate. Don't take chromium supplements, if you already have liver disease. Diabetes: Chromium might lower blood sugar levels too much if taken along with diabetes medications. If you have diabetes, use chromium products cautiously and monitor blood glucose levels closely. Dose adjustments to diabetes medications might be necessary.
Do not use this medication if you are allergic to repaglinide, if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis call your doctor for treatment with insulin. You should not use repaglinide together with gemfibrozil Lopid or NPH insulin such as isophane insulin. CLD classified by Child-Pugh scale and clearance. Other medications can affect the removal of repaglinide from your body, which may affect how repaglinide works. Examples include clopidogrel, gemfibrozil, trimethoprim, azole antifungals such as itraconazole macrolide antibiotics such as erythromycin rifamycins such as rifabutin St. John's wort, among others.